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                            你的位置:首頁 > 產品展示 > 離子通道研究用多肽毒素 > smartox biotech蛛毒素 >ω-Conotoxin-SO3 (ω-漏斗網蛛毒素SO3 )

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                            ω-Conotoxin-SO3 (ω-漏斗網蛛毒素SO3 )

                            簡要描述:Smartox Biotechnology是*一家專門生產動物毒液多肽毒素,用于細胞離子通道功能研究的生物醫藥公司。多肽毒素在生物制藥領域具有重要的使用價值。

                            • 產品型號:08CON013
                            • 廠商性質:代理商
                            • 更新時間:2024-10-30
                            • 訪  問  量:2004

                            產品介紹

                            ω-Conotoxin-SO3 (ω-漏斗網蛛毒素SO3 ) 

                            Selective blocker of N-type calcium channels

                            N型鈣通道選擇性阻斷劑

                             

                            ω-conotoxin SO-3 is a selective blocker of N-type voltage-sensitive calcium channels. EC50 for ω-conotoxin SO-3 is 0.16 µM (similar to ω-conotoxin MVIIA) on HVA calcium currents. ω-conotoxin SO-3 did not show any inhibiting effects on L-type, P/Q-type and R-type currents at 3 µM concentration. ω-conotoxin SO-3 has no effect on voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. At 3 µM, the inhibition amounts of HVA ICa was very similar between ω-conotoxin SO-3 and ω-conotoxin MVIIA (~ 32%). Their inhibitory effects are almost fully reversible but their half-time for recovery are different (~ 7.5 min for ω-conotoxin SO-3 and  ~ 4.14 min for ω-conotoxin MVIIA). ω-conotoxin SO-3 displays an analgesic potency similar to ω-conotoxin MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of ω-conotoxin MVIIA injected intrathecally.

                             

                            ω-Conotoxin-SO3 (ω-漏斗網蛛毒素SO3 )技術資料

                             

                            氨基酸序列:

                            Cys1-Lys-Ala-Ala-Gly-Lys-Pro-Cys8-Ser-Arg-Ile-Ala-Tyr-Asn-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2 

                            二硫鍵:Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25 

                            長度 (aa)25

                            分子式: C100H165N35O32S6 

                            分子量: 2567.07 Da

                            外觀:White lyophilized solid

                            可溶性: water and saline buffer

                            CAS 號:not available 

                            來源:Synthetic

                            純度:> 97 %

                             

                            產品信息

                            08CON013-00100

                            ω-conotoxin SO3(ω-漏斗網蛛毒素SO3 )

                                   0.1mg

                             

                            08CON013-00500

                            ω-conotoxin SO3(ω-漏斗網蛛毒素SO3 )

                            0.5mg

                             

                            08CON013-01000

                            ω-conotoxin SO3(ω-漏斗網蛛毒素SO3

                            1mg

                             

                             

                             

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